Could preoperative short-course radiotherapy be the treatment of choice for localized advanced rectal carcinoma?

morbidity and mortality following short course preoperative radiotherapy in rectal carcinoma

the aim of this study was to evaluate the morbidity and mortality in patients with operable stage ii and iii rectal cancers within one or two months after surgery, who has been treated pre-operatively with short course radiotherapy. twenty-eight patients with rectal adenocarcinoma, consecutively referred to the cancer institute of imam khomeini hospital from march 2009 to march 2010, were selec...

Morbidity and Mortality Following Short Course Preoperative Radiotherapy in Rectal Carcinoma.

The aim of this study was to evaluate the morbidity and mortality in patients with operable stage II and III rectal cancers within one or two months after surgery, who has been treated pre-operatively with short course radiotherapy. Twenty-eight patients with rectal adenocarcinoma, consecutively referred to the Cancer Institute of Imam Khomeini Hospital from March 2009 to March 2010, were selec...

Upfront systemic chemotherapy and preoperative short-course radiotherapy with delayed surgery for locally advanced rectal cancer with distant metastases

BACKGROUND Choosing the most effective approach for treating rectal cancer with mesorectal fascia (MRF) involvement or closeness and synchronous distant metastases is a current clinical challenge. The aim of this retrospective study was to determine if upfront systemic chemotherapy and short-course radiotherapy (RT) with delayed surgery enables R0 resection. METHODS Between March 2009 and Oct...

Preoperative short-course radiotherapy in locally advanced rectal cancer: the attitude on how to use radiotherapy in rectal cancer is changing.

Short-versus Long-course Preoperative Radiotherapy plus Delayed Surgery for Rectal Cancer: a Meta-analysis

Long-course chemo-radiotherapy (45~50 Gy in 25 fractions) with delayed surgery or short-course radiotherapy (25 Gy in 5 fractions) with immediate surgery were the most frequent regimens for the treatment of localized and locally advanced resectable rectal cancer (SWEDISH RECTAL CANCER TRIAL, 1997; Colorectal Cancer Collaborative Group, 2001; Kapiteijn et al., 2001; Sauer et al., 2004). Compared...